Mitofusin 2 Is Essential for IP₃-Mediated SR/Mitochondria Metabolic Feedback in Ventricular Myocytes.

ABSTRACT: Aim: Endothelin-1 (ET-1) and angiotensin II (Ang II) are multifunctional peptide hormones that regulate the function of the cardiovascular and renal systems. Both hormones increase the intracellular production of inositol-1,4,5-trisphosphate (IP₃) by activating their membrane-bound receptors. We have previously demonstrated that IP₃-mediated sarcoplasmic reticulum (SR) Ca²⁺ release results in mitochondrial Ca²⁺ uptake and activation of ATP production. In this study, we tested the hypothesis that intact SR/mitochondria microdomains are required for metabolic IP₃-mediated SR/mitochondrial feedback in ventricular myocytes. Methods: As a model for disrupted mitochondrial/SR microdomains, cardio-specific tamoxifen-inducible mi

SUBMITTER: Seidlmayer LK 

PROVIDER: S-EPMC6658196 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature