Intracellular compartment-specific proteasome dysfunction in postmortem cortex in schizophrenia subjects.

ABSTRACT: Protein homeostasis is an emerging component of schizophrenia (SZ) pathophysiology. Proteomic alterations in SZ are well-documented and changes in transcript expression are frequently not associated with changes in protein expression in SZ brain. The underlying mechanism driving these changes remains unknown, though altered expression of ubiquitin proteasome system (UPS) components have implicated protein degradation. Previous studies have been limited to protein and transcript expression, however, and do not directly test the function of the proteasome. To address this gap in knowledge, we measured enzymatic activity associated with the proteasome (chymotrypsin-, trypsin-, and caspase-like) in the superior temporal gyrus (STG) of 25 SZ and 25 comparison subjects using flourogenic substrat

SUBMITTER: Scott MR 

PROVIDER: S-EPMC6658356 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature