DT-678 inhibits platelet activation with lower tendency for bleeding compared to existing P2Y₁₂ antagonists.

ABSTRACT: The novel clopidogrel conjugate, DT-678, is an effective inhibitor of platelets and thrombosis in preclinical studies. However, a comparison of the bleeding risk with DT-678 and currently approved P2Y₁₂ antagonists has yet to be determined. The objective of this study was to evaluate the bleeding tendency of animals treated with clopidogrel, ticagrelor, and DT-678. Ninety-one New Zealand white rabbits were randomized to one of 13 treatment groups (n = 7). Platelet activation was assessed by flow cytometry and light transmission aggregometry before and after the administration of various doses of DT-678, clopidogrel, and ticagrelor. Tongue template bleeding times were also measured before and after drug treatment. Treatment with P2Y₁₂ receptor antagonists caused a dose

SUBMITTER: Lauver DA 

PROVIDER: S-EPMC6658415 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature