Clinicopathological and epidemiological significance of breast cancer subtype reclassification based on p53 immunohistochemical expression.

ABSTRACT: TP53 mutations are common in breast cancer and are typically associated with more aggressive tumor characteristics, but little is known about the clinicopathological and epidemiological relevance of p53 protein expression, a TP53 mutation surrogate, in breast cancer subtypes. In this study of 7226 Chinese women with invasive breast cancer, we defined breast cancer subtypes using immunohistochemical (IHC) measures of hormone receptors and HER2 in conjunction with histologic grade. p53 expression status was then used to further stratify subtypes into p53-positive and p53-negative. Odds ratios (ORs) and 95% confidence intervals (CIs) in case-only logistic regression analyses were used to examine heterogeneity across different subtypes. The frequency of p53 protein expression var

SUBMITTER: Abubakar M 

PROVIDER: S-EPMC6658470 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature