FDA-ARGOS is a database with public quality-controlled reference genomes for diagnostic use and regulatory science.

ABSTRACT: FDA proactively invests in tools to support innovation of emerging technologies, such as infectious disease next generation sequencing (ID-NGS). Here, we introduce FDA-ARGOS quality-controlled reference genomes as a public database for diagnostic purposes and demonstrate its utility on the example of two use cases. We provide quality control metrics for the FDA-ARGOS genomic database resource and outline the need for genome quality gap filling in the public domain. In the first use case, we show more accurate microbial identification of Enterococcus avium from metagenomic samples with FDA-ARGOS reference genomes compared to non-curated GenBank genomes. In the second use case, we demonstrate the utility of FDA-ARGOS reference genomes for Ebola virus target sequence comparison as part of a c

SUBMITTER: Sichtig H 

PROVIDER: S-EPMC6658474 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature