Targeting cathepsin K diminishes prostate cancer establishment and growth in murine bone.

ABSTRACT:

Background

The processes of prostate cancer (PCa) invasion and metastasis are facilitated by proteolytic cascade involving multiple proteases, such as matrix metalloproteinases, serine proteases and cysteine proteases including cathepsin K (CatK). CatK is predominantly secreted by osteoclasts and specifically degrades collagen I leading to bone destruction. PCa and breast cancer preferentially metastasize to the bone. Importantly, CatK expression level is greater in PCa bone metastatic sites compared to primary tumor and normal prostate tissues. However, the underlying mechanism of CatK during PCa metastases into the bone remains to be elucidated. We investigated the functional role of CatK during the PCa establishment and growth process in the murine bone.

Methods

CatK mRNA

SUBMITTER: Liang W 

PROVIDER: S-EPMC6658578 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature