Dependency Between Protein-Protein Interactions and Protein Variability and Evolutionary Rates in Vertebrates: Observed Relationships and Stochastic Modeling.

ABSTRACT: Recent developments in sequencing and growth of bioinformatics resources provide us with vast depositories of protein network and single nucleotide polymorphism data. It allows us to re-examine, on a larger and more comprehensive scale, the relationship between protein-protein interactions and protein variability and evolutionary rates. This relationship has remained far from unambiguously resolved for quite a long time, reflecting shifting analysis approaches in the literature, and growing data availability. In this study, we utilized several public genomic databases to investigate this relationship in human, mouse, pig, chicken, and zebrafish. We observed strong non-linear relationship patterns (tending towards convex decreasing function shapes) between protein variability and the densit

SUBMITTER: Wang X 

PROVIDER: S-EPMC6658588 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature