Mechanical Function of the Nucleus in Force Generation during Epithelial Morphogenesis.

ABSTRACT: Mechanical forces are critical regulators of cell shape changes and developmental morphogenetic processes. Forces generated along the epithelium apico-basal cell axis have recently emerged as essential for tissue remodeling in three dimensions. Yet the cellular machinery underlying those orthogonal forces remains poorly described. We found that during Drosophila leg folding cells eventually committed to die produce apico-basal forces through the formation of a dynamic actomyosin contractile tether connecting the apical surface to a basally relocalized nucleus. We show that the nucleus is anchored to basal adhesions by a basal F-actin network and constitutes an essential component of the force-producing machinery. Finally, we demonstrate force transmission to the apical surface and the basa

SUBMITTER: Ambrosini A 

PROVIDER: S-EPMC6658619 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature