Radiomic detection of microscopic tumorous lesions in small animal liver SPECT imaging.

ABSTRACT:

Background

Our aim was to present a new data analysis technique for the early detection of tumorous lesions using single-photon emission computed tomography (SPECT) imaging. Beyond standardized uptake value (SUV) and standardized uptake concentration (SUC), the skewness and kurtosis parameters of whole liver activity distribution histograms were examined in SPECT images to reveal the presence of tumorous cells.

Methods

Four groups of mice were used in our experiment: a healthy control group, a group of obese mice with high body mass index, and two tumorous groups (primary liver cancer group with chemically induced hepatocellular carcinoma (HCC); metastatic liver tumor group-xenograft of human melanoma (HM)). For the SPECT measurements, ^99mTc-labeled aggregated alb

SUBMITTER: Veres DS 

PROVIDER: S-EPMC6658620 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature