Development of a model for anemia of inflammation that is relevant to critical care.

ABSTRACT:

Background

Anemia of inflammation (AI) is common in critically ill patients. Although this syndrome negatively impacts the outcome of critical illness, understanding of its pathophysiology is limited. Also, new therapies that increase iron availability for erythropoiesis during AI are upcoming. A model of AI induced by bacterial infections that are relevant for the critically ill is currently not available. This paper describes the development of an animal model for AI that is relevant for critical care research.

Results

In experiments with rats, the rats were inoculated either repeatedly or with a slow release of Streptococcus pneumoniae or Pseudomonas aeruginosa. Rats became ill, but their hemoglobin levels remained stable. The use of a higher dose of bacteria resulted in

SUBMITTER: Boshuizen M 

PROVIDER: S-EPMC6658638 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature