Bedaquiline Eliminates Bactericidal Activity of β-Lactams against Mycobacterium abscessus.

ABSTRACT: The β-lactams imipenem and cefoxitin are used for the treatment of Mycobacterium abscessus lung infections. Here, we show that these cell wall synthesis inhibitors trigger a lethal bacterial ATP burst by increasing oxidative phosphorylation. Cotreatment of M. abscessus with the antimycobacterial ATP synthase inhibitor bedaquiline suppresses this ATP burst and eliminates the bactericidal activity of β-lactams. Thus, the addition of bedaquiline to β-lactam-containing regimes may negatively affect treatment outcome.

SUBMITTER: Lindman M 

PROVIDER: S-EPMC6658768 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature