Haemodynamics, dyspnoea, and pulmonary reserve in heart failure with preserved ejection fraction.

ABSTRACT:

Aims

Increases in left ventricular filling pressure are a fundamental haemodynamic abnormality in heart failure with preserved ejection fraction (HFpEF). However, very little is known regarding how elevated filling pressures cause pulmonary abnormalities or symptoms of dyspnoea. We sought to determine the relationships between simultaneously measured central haemodynamics, symptoms, and lung ventilatory and gas exchange abnormalities during exercise in HFpEF.

Methods and results

Subjects with invasively-proven HFpEF (n = 50) and non-cardiac causes of dyspnoea (controls, n = 24) underwent cardiac catheterization at rest and during exercise with simultaneous expired gas analysis. During submaximal (20 W) exercise, subjects with HFpEF displayed higher pulmonary capillary wedge

SUBMITTER: Obokata M 

PROVIDER: S-EPMC6658816 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature