Microstructural white matter network-connectivity in individuals with psychotic disorder, unaffected siblings and controls.

ABSTRACT: BACKGROUND:Altered structural network-connectivity has been reported in psychotic disorder but whether these alterations are associated with genetic vulnerability, and/or with phenotypic variation, has been less well examined. This study examined i) whether differences in network-connectivity exist between patients with psychotic disorder, siblings of patients with psychotic disorder and controls, and ii) whether network-connectivity alterations vary with (subclinical) symptomatology. METHODS:Network-connectivity measures (global efficiency (GE), density, local efficiency (LE), clustering coefficient (CC)) were derived from diffusion weighted imaging (DWI) and were compared between 85 patients with psychotic disorder, 93 siblings without psychotic disorder and 80 healthy comparison subject

SUBMITTER: Michielse S 

PROVIDER: S-EPMC6658824 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature