Somatic symptoms disorders in Parkinson's disease are related to default mode and salience network dysfunction.

ABSTRACT: BACKGROUND:Somatic Symptoms Disorder (SSD) has been shown to have a clinically very high prevalence in Parkinson's Disease (PD) with frequencies ranging from 7.0% to 66.7%, higher than in the general population (10%- 25%). SSD has been associated with dysfunction in Default Mode and Salience network. AIM:With the present study we aim to verify by means of resting state functional MRI whether possible specific abnormalities in the activation and functional connectivity of the default mode network (DMN) and salience network in cognitively intact PD patients may be more prominent in PD patients with somatic symptoms (SSD-PD) as compared with patients without SSD (PD). METHODS:Eighteen SSD-PD patients (61% male), 18 PD patients (83% male) and 22 healthy age-matched subjects (59% male) were enr

SUBMITTER: Franciotti R 

PROVIDER: S-EPMC6658828 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature