Immune Signature-Based Subtypes of Cervical Squamous Cell Carcinoma Tightly Associated with Human Papillomavirus Type 16 Expression, Molecular Features, and Clinical Outcome.

ABSTRACT: Substantial heterogeneity exists within cervical cancer that is generally infected by human papillomavirus (HPV). However, the most common histological subtype of cervical cancer, cervical squamous cell carcinoma (CSCC), is poorly characterized regarding the association between its heterogeneity and HPV oncoprotein expression. We filtered out 138 CSCC samples with infection of HPV16 only as the first step; then we compressed HPV16 E6/E7 expression as HPV_pca and correlated HPV_pca with the immunological profiling of CSCC based on supervised clustering to discover subtypes and to characterize the differences between subgroups in terms of the HPV_pca level, pathway activity, epigenetic dysregulation, somatic mutation frequencies, and likelihood of responding to

SUBMITTER: Lu X 

PROVIDER: S-EPMC6658934 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature