Association between genetically predicted polycystic ovary syndrome and ovarian cancer: a Mendelian randomization study.

ABSTRACT:

Background

Polycystic ovary syndrome (PCOS) is a complex endocrine disorder with an estimated prevalence of 4-21% in reproductive aged women. Recently, the Ovarian Cancer Association Consortium (OCAC) reported a decreased risk of invasive ovarian cancer among women with self-reported PCOS. However, given the limitations of self-reported PCOS, the validity of these observed associations remains uncertain. Therefore, we sought to use Mendelian randomization with genetic markers as a proxy for PCOS, to examine the association between PCOS and ovarian cancer.

Methods

Utilizing 14 single nucleotide polymorphisms (SNPs) previously associated with PCOS we assessed the association between genetically predicted PCOS and ovarian cancer risk, overall and by histotype, using summary sta

SUBMITTER: Harris HR 

PROVIDER: S-EPMC6659359 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature