Use of a pooled cohort to impute cardiovascular disease risk factors across the adult life course.

ABSTRACT:

Background

In designing prevention strategies, it may be useful to understand how early and midlife cardiovascular disease risk factor (CVDRF) exposures affect outcomes that primarily occur in mid to late life. Few single US cohorts have followed participants from early adulthood to late life.

Methods

We pooled four prospective cohorts that represent segments of the adult life course, and studied 15 001 White and Black adults aged 18 to 95 years at enrollment. We imputed early and midlife exposure to body mass index (BMI), glucose, lipids and blood pressure (BP). CVDRF trajectories were estimated using linear mixed models. Using the best linear unbiased predictions, we obtained person-specific estimates of CVDRF trajectories beginning at age 20 until each participant's end o

SUBMITTER: Zeki Al Hazzouri A 

PROVIDER: S-EPMC6659365 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature