Sex hormone binding globulin and risk of breast cancer: a Mendelian randomization study.

ABSTRACT:

Background

There are observational data suggesting an inverse association between circulating concentrations of sex hormone binding globulin (SHBG) and risk of postmenopausal breast cancer. However, causality is uncertain and few studies have investigated this association by tumour receptor status. We aimed to investigate these associations under the causal framework of Mendelian randomization (MR).

Methods

We used summary association estimates extracted from published genome-wide association study (GWAS) meta-analyses for SHBG and breast cancer, to perform two-sample MR analyses. Summary statistics were available for 122 977 overall breast cancer cases, of which 69 501 were estrogen receptor positive (ER+ve) and 21 468 were ER-ve, and 105 974 controls. To control for potent

SUBMITTER: Dimou NL 

PROVIDER: S-EPMC6659370 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature