The genetic interplay between body mass index, breast size and breast cancer risk: a Mendelian randomization analysis.

ABSTRACT:

Background

Evidence linking breast size to breast cancer risk has been inconsistent, and its interpretation is often hampered by confounding factors such as body mass index (BMI). Here, we used linkage disequilibrium score regression and two-sample Mendelian randomization (MR) to examine the genetic associations between BMI, breast size and breast cancer risk.

Methods

Summary-level genotype data from 23andMe, Inc (breast size, n = 33 790), the Breast Cancer Association Consortium (breast cancer risk, n = 228 951) and the Genetic Investigation of ANthropometric Traits (BMI, n = 183 507) were used for our analyses. In assessing causal relationships, four complementary MR techniques [inverse variance weighted (IVW), weighted median, weighted mode and MR-Egger regression] were u

SUBMITTER: Ooi BNS 

PROVIDER: S-EPMC6659372 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature