The relationship between sleep duration, cognition and dementia: a Mendelian randomization study.

ABSTRACT:

Background

Short and long sleep duration have been linked with poorer cognitive outcomes, but it remains unclear whether these associations are causal.

Methods

We conducted the first Mendelian randomization (MR) study with 77 single-nucleotide polymorphisms (SNPs) for sleep duration using individual-participant data from the UK Biobank cohort (N = 395 803) and summary statistics from the International Genomics of Alzheimer's Project (N cases/controls = 17 008/37 154) to investigate the potential impact of sleep duration on cognitive outcomes.

Results

Linear MR suggested that each additional hour/day of sleep was associated with 1% [95% confidence interval (CI) = 0-2%; P = 0.008] slower reaction time and 3% more errors in visual-memory test (95% CI = 0-6%; P = 0.05). T

SUBMITTER: Henry A 

PROVIDER: S-EPMC6659373 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature