Widespread microglial activation in multiple system atrophy.

ABSTRACT:

Background

The pattern and role of microglial activation in multiple system atrophy is largely unclear. The objective of this study was to use [¹¹ C](R)-PK11195 PET to determine the extent and correlation of activated microglia with clinical parameters in MSA patients.

Methods

Fourteen patients with the parkinsonian phenotype of MSA (MSA-P) with a mean disease duration of 2.9 years (range 2-5 years) were examined with [¹¹ C](R)-PK11195 PET and compared with 10 healthy controls.

Results

Patients with the parkinsonian phenotype of MSA showed a significant (P ≤ 0.01) mean increase in binding potentials compared with healthy controls in the caudate nucleus, putamen, pallidum, precentral gyrus, orbitofrontal cortex, presubgenual anterior cingulate cor

SUBMITTER: Kubler D 

PROVIDER: S-EPMC6659386 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature