Regulation of antitumour CD8 T-cell immunity and checkpoint blockade immunotherapy by Neuropilin-1.

ABSTRACT: Neuropilin-1 (Nrp-1) is a marker for murine CD4⁺FoxP3⁺ regulatory T (Treg) cells, a subset of human CD4⁺ Treg cells, and a population of CD8⁺ T cells infiltrating certain solid tumours. However, whether Nrp-1 regulates tumour-specific CD8 T-cell responses is still unclear. Here we show that Nrp-1 defines a subset of CD8⁺ T cells displaying PD-1^hi status and infiltrating human lung cancer. Interaction of Nrp-1 with its ligand semaphorin-3A inhibits migration and tumour-specific lytic function of cytotoxic T lymphocytes. In vivo, Nrp-1⁺PD-1^hi CD8⁺ tumour-infiltrating lymphocytes (TIL) in B16F10 melanoma are enriched for tumour-reactive T cells exhibiting an exhausted state, expressing Tim-3, LA

SUBMITTER: Leclerc M 

PROVIDER: S-EPMC6659631 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature