Association of tagSNPs at lncRNA MALAT-1 with HCC Susceptibility in a Southern Chinese Population.

ABSTRACT: As a long non-coding RNA (lncRNA) and a transcriptional regulator, Metastasis associated lung adenocarcioma transcript-1 (MALAT-1) has been reported to be associated with proliferation and metastasis of hepatocellular carcinoma (HCC). However, the effects of MALAT-1 single nucleotide polymorphisms (SNPs) on HCC remains poorly understood. This study, including 624 HCC cases and 618 controls, aimed to explore the potential associations between three common tagSNPs at MALAT-1 and HCC risk in a Southern Chinese population. No significant associations were observed between the three tagSNPs and HCC risk under any genetic models after adjusting for potential confounders. Additionally, there were no any significant associations in the stratified analysis, combined effect analysis, and multifactor

SUBMITTER: Ji X 

PROVIDER: S-EPMC6659651 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature