Novel eosinophilic gene expression networks associated with IgE in two distinct asthma populations.

ABSTRACT:

Background

Asthma represents a significant public health burden; however, novel biological therapies targeting immunoglobulin E (IgE)-mediated pathways have widened clinical treatment options for the disease.

Objective

In this study, we sought to identify gene transcripts and gene networks involved in the determination of serum IgE levels in people with asthma that can help inform the development of novel therapeutic agents.

Methods

We analysed gene expression data from a cross-sectional study of 326 Costa Rican children with asthma, aged 6 to 12 years, from the Genetics of Asthma in Costa Rica Study and 610 young adults with asthma, aged 16 to 25 years, from the Childhood Asthma Management Program trial. We utilized differential gene expression analysis and performed

SUBMITTER: Virkud YV 

PROVIDER: S-EPMC6659730 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature