Acoustic droplet vaporization-mediated dissolved oxygen scavenging in blood-mimicking fluids, plasma, and blood.

ABSTRACT: Acoustic droplet vaporization (ADV) has been shown to reduce the partial pressure of oxygen (PO₂) in a fluid. The goals of this study were three-fold: 1) to determine the ADV pressure amplitude threshold in fluids that had physiologically relevant values for surface tension, protein concentration, and viscosity; 2) to assess whether these parameters and fluid mixing affect ADV-mediated PO₂ reduction; and 3) to assess the feasibility of ADV-mediated PO₂ reduction in plasma and whole blood. In vitro ADV experiments were conducted using perfluoropentane droplets (number density: 5 × 10⁶ ± 0.2 × 10⁶/mL) dispersed in fluids (saline, polyvinylpyrrolidone solutions, porcine plasma, or porcine whole blood) that had a physiological range of sur

SUBMITTER: Mercado-Shekhar KP 

PROVIDER: S-EPMC6659737 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature