Genome-wide association study identifies CD1A associated with rate of increase in plasma neurofilament light in non-demented elders.

ABSTRACT: As a marker of neuroaxonal injury, neurofilament light (NFL) in blood is robustly elevated in many neurodegenerative conditions. We aimed to discover single nucleotide polymorphisms (SNPs) associated with longitudinal changes in plasma NFL levels that affect the risk of developing neurodegenerative disease and clinical disease progression. 545 eligible non-Hispanic white participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI) with longitudinal plasma NFL data were included. Three SNPs (rs16840041, p=4.50×10^-8; rs2269714, p=4.50×10^-8; rs2269715, p=4.83×10^-8) in CD1A were in high linkage disequilibrium (LD) and significantly associated with the increase in plasma NFL levels. We demonstrate a promoting effect of rs16840041-A on clinical

SUBMITTER: Wang ZT 

PROVIDER: S-EPMC6660034 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature