Assessment of ERBB2 and TOP2α gene status and expression profile in feline mammary tumors: findings and guidelines.

ABSTRACT: In humans, the ERBB2 gene amplification and overexpression are biomarkers for invasive breast cancer and a therapeutic target. Also, TOP2α gene aberrations predict the response to anthracycline-based adjuvant chemotherapy. Although feline mammary tumors (FMTs) are good models in comparative oncology, scarce data is available regarding the ERBB2 and TOP2α status. In this study, and for the first time, the ERBB2 DNA status and RNA levels of intracellular (ICD) and extracellular (ECD) coding regions were compared with TOP2α gene status and expression profile, in samples of FMTs and disease-free tissues from the same animal. Results showed that ERBB2 and TOP2α gene status are highly correlated (r=0.87, p<0.0001, n=25), with few tumor samp

SUBMITTER: Ferreira D 

PROVIDER: S-EPMC6660035 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature