Analyzing pharmacological intervention points: A method to calculate external stimuli to switch between steady states in regulatory networks.

ABSTRACT: Once biological systems are modeled by regulatory networks, the next step is to include external stimuli, which model the experimental possibilities to affect the activity level of certain network's nodes, in a mathematical framework. Then, this framework can be interpreted as a mathematical optimal control framework such that optimization algorithms can be used to determine external stimuli which cause a desired switch from an initial state of the network to another final state. These external stimuli are the intervention points for the corresponding biological experiment to obtain the desired outcome of the considered experiment. In this work, the model of regulatory networks is extended to controlled regulatory networks. For this purpose, external stimuli are considered which can affect

SUBMITTER: Breitenbach T 

PROVIDER: S-EPMC6660093 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature