Preclinical insights into cholangiopathies: disease modeling and emerging therapeutic targets.

ABSTRACT:

Introduction

The common predominant clinical features of cholangiopathies such as primary sclerosing cholangitis (PSC), primary biliary cholangitis (PBC), and biliary atresia (BA) are biliary damage/senescence and liver fibrosis. Curative therapies are lacking, and liver transplantation is the only option. An understanding of the mechanisms and pathogenesis is needed to develop novel therapies. Previous studies have developed various disease-based research models and have identified candidate therapeutic targets. Areas covered: This review summarizes recent studies performed in preclinical models of cholangiopathies and the current understanding of the pathophysiology representing potential targets for novel therapies. A literature search was conducted in PubMed using the combinati

SUBMITTER: Sato K 

PROVIDER: S-EPMC6660346 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature