Relationships between neural activation during a reward task and peripheral cytokine levels in youth with diverse psychiatric symptoms.

ABSTRACT:

Background

Inflammation has been hypothesized to contribute to reward dysfunction across psychiatric conditions, but little is known about this relationship in youth. Therefore, the present study investigated the associations between general and specific markers of inflammation and neural activation during reward processing, including anticipation and attainment, in youth with diverse psychiatric symptoms.

Methods

Forty-six psychotropic medication-free youth with diverse psychiatric symptoms underwent a blood draw to measure 41 cytokines, as well as structural and functional magnetic resonance imaging. The Reward Flanker Task examined neural activation during reward anticipation and attainment. Relationships between inflammation and neural activation were assessed using data

SUBMITTER: Bradley KA 

PROVIDER: S-EPMC6660409 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature