Durvalumab in Combination with Olaparib in Patients with Relapsed SCLC: Results from a Phase II Study.

ABSTRACT:

Purpose

Despite high tumor mutationburden, immune checkpoint blockade has limited efficacy in SCLC. We hypothesized that poly (ADP-ribose) polymerase inhibition could render SCLC more susceptible to immune checkpoint blockade.

Methods

A single-arm, phase II trial (NCT02484404) enrolled patients with relapsed SCLC who received durvalumab, 1500 mg every 4 weeks, and olaparib, 300 mg twice a day. The primary outcome was objective response rate. Correlative studies included mandatory collection of pretreatment and during-treatment biopsy specimens, which were assessed to define SCLC immunephenotypes: desert (CD8-positive T-cell prevalence low), excluded (CD8-positive T cells in stroma immediately adjacent/within tumor), and inflamed (CD8-positive T cells in direct contact with t

SUBMITTER: Thomas A 

PROVIDER: S-EPMC6660419 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature