Malaria early in the first pregnancy: Potential impact of iron status.

ABSTRACT:

Background & aims

Low iron stores may protect from malaria infection, therefore improving iron stores in early pregnancy in line with current recommendations could increase malaria susceptibility. To test this hypothesis we compared iron biomarkers and red cell indices in nulliparae and primigravidae who participated in a randomized controlled trial of long-term weekly iron supplementation.

Methods

Cross-sectional and longitudinal data analysis from a randomized controlled trial of long-term weekly iron supplementation in rural Burkina Faso. Malaria parasitaemia was monitored and biomarkers and red cell indices measured at study end-points: plasma ferritin, transferrin receptor (sTfR), zinc protoporphyrin, hepcidin, sTfR/log₁₀ ferritin ratio, body iron, haemoglobi

SUBMITTER: Diallo S 

PROVIDER: S-EPMC6660428 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature