Spiked human substantia nigra proteome data set for use as a spectral library for protein modelling and protein mapping.

ABSTRACT: This article describes a mass spectrometric data set generated from human substantia nigra tissue that was spiked with iRT peptides. The data set can be used as a spectral library for analysis of the human brain; especially for analysis of human substantia nigra, for example, in the context of Parkinson's disease. Obtaining a sufficient amount of high-quality substantia nigra tissue is the key limiting factor for establishing a brain region-specific spectral library. Hence, combining existing spectral libraries for data-independent acquisition analysis (DIA) can overcome this major limitation. Moreover, these data can be used to map brain region-specific proteins and to model brain region-specific pathways. Both can improve our understanding of the functioning of the b

SUBMITTER: Steinbach S 

PROVIDER: S-EPMC6660433 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature