YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity.

ABSTRACT: Fibroblast growth factor 21 (FGF21) is an endocrine hormone that regulates glucose, lipid, and energy homeostasis. While gene expression of FGF21 is regulated by the nuclear hormone receptor peroxisome proliferator-activated receptor alpha in the fasted state, little is known about the regulation of trafficking and secretion of FGF21. We show that mice with a mutation in the Yip1 domain family, member 6 gene (Klein-Zschocher [KLZ]; Yipf6^KLZ/Y ) on a high-fat diet (HFD) have higher plasma levels of FGF21 than mice that do not carry this mutation (controls) and hepatocytes from Yipf6^KLZ/Y mice secrete more FGF21 than hepatocytes from wild-type mice. Consequently, Yipf6^KLZ/Y mice are resistant to H

SUBMITTER: Wang L 

PROVIDER: S-EPMC6660779 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature