Management of low-grade glioma: a systematic review and meta-analysis.

ABSTRACT:

Background

Optimum management of low-grade gliomas remains controversial, and widespread practice variation exists. This evidence-based meta-analysis evaluates the association of extent of resection, radiation, and chemotherapy with mortality and progression-free survival at 2, 5, and 10 years in patients with low-grade glioma.

Methods

A quantitative systematic review was performed. Inclusion criteria included controlled trials of newly diagnosed low-grade (World Health Organization Grades I and II) gliomas in adults. Eligible studies were identified, assigned a level of evidence for every endpoint considered, and analyzed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The relative risk of mortality and of progression at 2, 5, and

SUBMITTER: Brown TJ 

PROVIDER: S-EPMC6660818 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature