Chemotherapy and diffuse low-grade gliomas: a survey within the European Low-Grade Glioma Network.

ABSTRACT:

Background

Diffuse low-grade gliomas (DLGGs) are rare and incurable tumors. Whereas maximal safe, functional-based surgical resection is the first-line treatment, the timing and choice of further treatments (chemotherapy, radiation therapy, or combined treatments) remain controversial.

Methods

An online survey on the management of DLGG patients was sent to 28 expert centers from the European Low-Grade Glioma Network (ELGGN) in May 2015. It contained 40 specific questions addressing the modalities of use of chemotherapy in these patients.

Results

The survey demonstrated a significant heterogeneity in practice regarding the initial management of DLGG patients and the use of chemotherapy. Interestingly, radiation therapy combined with the procarbazine, CCNU (lomustine),

SUBMITTER: Darlix A 

PROVIDER: S-EPMC6660823 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature