Quantification of porcine myocardial perfusion with modified dual bolus MRI - a prospective study with a PET reference.

ABSTRACT:

Background

The reliable quantification of myocardial blood flow (MBF) with MRI, necessitates the correction of errors in arterial input function (AIF) caused by the T1 saturation effect. The aim of this study was to compare MBF determined by a traditional dual bolus method against a modified dual bolus approach and to evaluate both methods against PET in a porcine model of myocardial ischemia.

Methods

Local myocardial ischemia was induced in five pigs, which were subsequently examined with contrast enhanced MRI (gadoteric acid) and PET (O-15 water). In the determination of MBF, the initial high concentration AIF was corrected using the ratio of low and high contrast AIF areas, normalized according to the corresponding heart rates. MBF was determined from the MRI, during stre

SUBMITTER: Husso M 

PROVIDER: S-EPMC6660956 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature