Relaxin inhibits patellar tendon healing in rats: a histological and biochemical evaluation.

ABSTRACT:

Background

Female patients are more likely to have tendon injuries than males, especially those who has a higher concentration of relaxin. Previous studies have demonstrated that relaxin attenuates extracellular matrix (ECM) formation. However, the mechanism of relaxin on tendon repair remains unclear. We hypothesize that relaxin inhibits tendon healing by disrupting collagen synthesis.

Methods

A patellar tendon window defect model was established using Sprague-Dawley rats. The center of the patellar tendon was removed from the patella distal apex and inserted to the tibia tuberosity in width of 1 mm. Then, the rats were injected with saline (0.2 μg/kg/day) or relaxin (0.2 μg/kg/day) for two and four weeks, which was followed by biomechanical analysis and histological and hi

SUBMITTER: Xu T 

PROVIDER: S-EPMC6661089 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature