Tau and atrophy: domain-specific relationships with cognition.

ABSTRACT:

Background

Late-onset Alzheimer's disease (AD) is characterized by primary memory impairment, which then progresses towards severe deficits across cognitive domains. Here, we report how performance in cognitive domains relates to patterns of tau deposition and cortical thickness.

Methods

We analyzed data from 131 amyloid-β positive participants (55 cognitively normal, 46 mild cognitive impairment, 30 AD) of the Alzheimer's Disease Neuroimaging Initiative who underwent magnetic resonance imaging (MRI), flortaucipir (FTP) positron emission tomography, and neuropsychological testing. Surface-based vertex-wise and region-of-interest analyses were conducted between FTP and cognitive test scores, and between cortical thickness and cognitive test scores.

Results

FTP and thic

SUBMITTER: Digma LA 

PROVIDER: S-EPMC6661099 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature