Catalytic Alkyne Arylation Using Traceless Directing Groups.

ABSTRACT: By using Pd⁰ /Mandyphos, we achieved a three-component aminoarylation of alkynes to generate enamines, which are then hydrolyzed to either α-arylphenones or α,α-diarylketones. This Pd-catalyzed method overcomes established known pathways to enable the use of amines as traceless directing groups for C-C bond formation.

SUBMITTER: Park JW 

PROVIDER: S-EPMC6661160 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature