Cochrane systematic review and meta-analysis of botulinum toxin for the prevention of migraine.

ABSTRACT:

Objectives

To assess the effects of botulinum toxin for prevention of migraine in adults.

Design

Systematic review and meta-analysis.

Data sources

CENTRAL, MEDLINE, Embase and trial registries.

Eligibility criteria

We included randomised controlled trials (RCTs) of botulinum toxin compared with placebo, active treatment or clinically relevant different dose for adults with chronic or episodic migraine, with or without the additional diagnosis of medication overuse headache.

Data extraction and synthesis

Cochrane methods were used to review double-blind RCTs. Twelve week post-treatment time-point data was analysed.

Results

Twenty-eight trials (n=4190) were included. Trial quality was mixed. Botulinum toxin treatment resulted in reduced frequency of

SUBMITTER: Herd CP 

PROVIDER: S-EPMC6661560 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature