Pharmacological interventions for the prevention of fetal growth restriction: protocol for a systematic review and network meta-analysis.

ABSTRACT:

Introduction

Fetal growth restriction (FGR) includes different conditions in which a fetus fails to reach the own full growth, and accounts for 28%-45% of non-anomalous stillbirths. The management of FGR is based on the prolongation of pregnancy long enough for fetal organs to mature while preventing starvation. As for pharmacological management, most guidelines recommend treatment with low-dose aspirin and/or with heparin, although this approach is still controversial and innovative promising therapies are under investigation. As no firm evidence exists to guide clinicians towards the most effective therapeutic intervention, this protocol describes methods for a systematic review and network meta-analysis (NetMA) of pharmacological treatments for FGR prevention.

Methods and ana

SUBMITTER: Bettiol A 

PROVIDER: S-EPMC6661573 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature