In silico design and synthesis of hesperitin derivatives as new xanthine oxidase inhibitors.

ABSTRACT:

Background

Hesperitin, a naturally occurring flavonoid was hybridized with phenolic acids to evaluate its potential to inhibit the activity of xanthine oxidase (XO), a key enzyme which catalyses xanthine to uric acid which is found to be associated with gout and many life style related disorders.

Objective

To develop new xanthine oxidase inhibitors from natural constituents along with antioxidant potential.

Method

In this report, we designed and synthesized hesperitin derivatives hybridized with natural phenolic acids to form ester linkage with the help of molecular docking. The synthesized compounds were evaluated for their antioxidant and xanthine oxidase inhibitory potential.

Results

The in vitro xanthine oxidase inhibitory activity and enzyme kinetics studi

SUBMITTER: Malik N 

PROVIDER: S-EPMC6661729 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature