In silico design and synthesis of targeted rutin derivatives as xanthine oxidase inhibitors.

ABSTRACT:

Background

Xanthine oxidase is an important enzyme of purine catabolism pathway and has been associated directly in pathogenesis of gout and indirectly in many pathological conditions like cancer, diabetes and metabolic syndrome. In this research rutin, a bioactive flavonoid was explored to determine the capability of itself and its derivatives to inhibit xanthine oxidase.

Objective

To develop new xanthine oxidase inhibitors from natural constituents along with antioxidant potential.

Method

In this report, we designed and synthesized rutin derivatives hybridized with hydrazines to form hydrazides and natural acids to form ester linkage with the help of molecular docking. The synthesized compounds were evaluated for their antioxidant and xanthine oxidase inhibitory pot

SUBMITTER: Malik N 

PROVIDER: S-EPMC6661775 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature