Vitamin D metabolites are lower with active Crohn's disease and spontaneously recover with development of remission.

ABSTRACT:

Background

Vitamin D deficiency is associated with active Crohn's disease (CD). However, it remains unclear if lower 25-hydroxyvitamin D [25(OH)D] concentration is the cause, or consequence, of intestinal inflammation. Existing literature has focused on circulating 25(OH)D rather than the active metabolite 1,25(OH)₂D, or its breakdown product, 24,25(OH)₂D. We aimed to characterise vitamin D metabolism in a cohort of patients with active and inactive CD.

Methods

Fifty-four patients with CD and not on corticosteroids or vitamin D supplements, were enrolled in a 6-month prospective cohort study. Sera were collected on enrolment and at 6 months and tested for 25(OH)D, 1,25(OH)₂D, 24,25(OH)₂D using liquid chromatography tandem mass spec

SUBMITTER: Haifer C 

PROVIDER: S-EPMC6661794 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature