Precision medicine in adult and pediatric obesity: a clinical perspective.

ABSTRACT: It remains largely unknown as to why some individuals experience substantial weight loss with obesity interventions, while others receiving these same interventions do not. Person-specific characteristics likely play a significant role in this heterogeneity in treatment response. The practice of precision medicine accounts for an individual's genes, environment, and lifestyle when deciding upon treatment type and intensity in order to optimize benefit and minimize risk. In this review, we first discuss biopsychosocial determinants of obesity, as understanding the complexity of this disease is necessary for appreciating how difficult it is to develop individualized treatment plans. Next, we present literature on person-specific characteristics associated with, and predictive of, weight loss

SUBMITTER: Bomberg EM 

PROVIDER: S-EPMC6661805 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature