α-Glucosidase inhibitors from a mangrove associated fungus, Zasmidium sp. strain EM5-10.

ABSTRACT:

Background

Mangroves plants and their endophytes represent a natural source of novel and bioactive compounds. In our ongoing research on mangrove endophytes from the Panamanian Pacific Coast, we have identified several bioactive endophytic fungi. From these organisms, an isolate belonging to the genus Zasmidium (Mycosphaerellaceae) showed 91.3% of inhibition against α-glucosidase enzyme in vitro.

Results

Zasmidium sp. strain EM5-10 was isolated from mature leaves of Laguncularia racemosa, and its crude extract showed good inhibition against α-glucosidase enzyme (91.3% of inhibition). Bioassay-guided fractionation of the crude extract led to obtaining two active fractions: L (tripalmitin) and M (Fungal Tryglicerides Mixture). Tripalmitin (3.75 µM) showed

SUBMITTER: Lopez D 

PROVIDER: S-EPMC6661824 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature