Thiolation and characterization of regenerated Bombyx mori silk fibroin films with reduced glutathione.

ABSTRACT: Bombyx mori silk fibroin-based materials have good biocompatibility and biodegradability. In order to maximize their utility while maintain appropriate features, silk fibroin (SF) films were modified with reduced glutathione (GSH) (NH₂)-ECG-(COOH), using the carbodiimide chemistry method, for the introduction of thiol groups onto surfaces. The effects of this modification on SF films' chemical and physical properties, and cytotoxicity were assessed. The chemical and elemental composition analysis results suggested that reduced glutathione (GSH) was covalently coupled onto the surface of silk fibroin films. Atomic force microscopy (AFM) results indicated the surface roughness of silk fibroin film was increased after the modification by GSH. The GSH-modified silk fib

SUBMITTER: Zhang X 

PROVIDER: S-EPMC6661838 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature