Design, synthesis, and biological evaluation of novel N ⁴ -substituted sulfonamides: acetamides derivatives as dihydrofolate reductase (DHFR) inhibitors.

ABSTRACT:

Background

Sulfonamide derivatives are of great attention due to their wide spectrum of biological activities. Sulfonamides conjugated with acetamide fragments exhibit antimicrobial and anticancer activities. The inhibition dihydrofolate reductase (DHFR) is considered as one of the most prominent mechanism though which sulfonamide derivatives exhibits antimicrobial and antitumor activities.

Results

In this study, a new series of 2-(arylamino)acetamides and N-arylacetamides containing sulfonamide moieties were designed, synthesized, characterized and assessed for their antimicrobial activity and screened for cytotoxic activity against human lung carcinoma (A-549) and human breast carcinoma (MCF-7) cell lines. A molecular docking study was performed to identify the mode

SUBMITTER: Hussein EM 

PROVIDER: S-EPMC6661844 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature