An analysis of a multiple biomarker panel to better predict prostate cancer metastasis after radical prostatectomy.

ABSTRACT: A plethora of individual candidate biomarkers for predicting biochemical relapse in localized prostate cancer (PCa) have been proposed. Combined biomarkers may improve prognostication, and ensuring validation against more clinically relevant endpoints are required. The Australian PCa Research Centre NSW has contributed to numerous studies of molecular biomarkers associated with biochemical relapse. In the current study, these biomarkers were re-analyzed for biochemical relapse, metastatic relapse and PCa death with extended follow-up. Biomarkers of significance were then used to develop a combined prognostic model for clinical outcomes and validated in a large independent cohort. The discovery cohort (n = 324) was based on 12 biomarkers with a median follow-up of 16 years. Seven biomarkers

SUBMITTER: Zhang AY 

PROVIDER: S-EPMC6661891 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature